The Anti-Aging Franchise Boom Has Begun

A new class of longevity-focused clinics are selling hormones, peptides and other therapies to consumers who’ve grown comfortable with the idea of investing in their health

Wellness is one of the discretionary categories U.S. consumers say they’re least likely to cut when finances tighten, according to McKinsey’s 2025 Future of Wellness survey.

It’s also one that 4Ever Young is helping scale into a national franchise category.

The anti-aging and wellness franchise, which offers more than 100 service modalities including GLP-1s, hormone optimization, peptides and other longevity-supporting therapies, has grown to more than 70 locations. 

It plans to expand past 80 this year and has another 60-plus in development, fulfilling demand for treatments that go beyond aesthetics in favor of a long-term, personalized approach to aging and overall wellness.

Target growth markets include Chicago, Austin, Maryland, Virginia and New Jersey.

“Our franchise model is built around that evolution, with a membership model and diversified menu of services designed to sustain customer engagement and help them hit their goals as they age,” 4Ever Young co-CEO James Kapnick said.

Though it emphasizes its anti-aging therapies, clients will still find Botox and other injectables on the menu, as well as facial treatments. Clinical services are delivered by licensed providers, but franchisees themselves don’t need a medical background.

“The level of interest we’re seeing reflects how quickly the wellness category is evolving,” 4Ever Young‘s director of operations and development Amanda Hansen said.

While aging is inevitable, an emerging franchise category is ensuring that how we age isn’t. There are already more than 700 longevity clinics operating globally, according to a 2026 Market Intelo report. Considering the enthusiasm of wellness spending, that figure is likely just the start.

Part of the evolution could be tied to GLP-1s, which have normalized consumers to injectables and led to a “second wave” of wellness in which consumers are asking what comes next, according to LaserAway co-founder and CEO Scott Heckmann.

Though not a franchise, the aesthetic dermatology chain has grown to more than 215 clinics without closing a single location, recently marking its 20th anniversary. It also expanded its menu to include wellness injections, including glutathione, B12 and NAD+.

“These additions reflect where aesthetics are moving,” LaserAway executive vice president of sales Marla Esposito said.

Serotonin Centers is another player scaling fast in the anti-aging space. Founded by Retro Fitness founder Eric Casaburi, the franchise has been signing multi-unit development agreements across Dallas, Boston, Orange County and Nashville.

But there’s also a nod to its founder’s fitness roots with the recently launched Serotonin Partner Program, a platform that installs longevity suites directly inside gyms and health clubs that have underutilized space available. The services on the menu: hormone optimization, GLP-1 and GIP protocols, peptide therapies, NAD+ optimization, IV therapy, red light and hyperbaric oxygen.

“The operators that move early will be better positioned to become comprehensive performance, recovery and longevity destinations for their members,” Casaburi said.

Next Health is another franchise capitalizing on the longevity movement and touts a rather robust menu, including therapeutic plasma exchange and ozone therapy.

Last fall, it acquired Lindora from Xponential Fitness, which has been trimming its portfolio to refocus on its core boutique fitness brands. Founded by Dr. Darshan Shah, Next Health is targeting 150 U.S. locations by 2027. 

“We’re at the beginning of changing how healthcare functions in this country,” Dr. Shah told Athletech News last year. “There needs to be 1,000 Next Healths.”

Restore Hyper Wellness founder Jim Donnelly is also building in the space. His new venture, Humanaut Health, opened its first franchise in Palm Beach Gardens, Florida last year and has launched its Dallas location this month.

The Austin-based franchise is planning coast-to-coast expansion through the year and offers services such as hormone optimization, hyperbaric oxygen therapy, cryotherapy, biomarker testing, DEXA scans and regenerative medicine.